ACY1 explained

Aminoacylase-1 is an enzyme that in humans is encoded by the ACY1 gene.^{[1] [2] [3]}

Function

Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.^[3]

Further reading

• Miller YE, Minna JD, Gazdar AF . Lack of expression of aminoacylase-1 in small cell lung cancer. Evidence for inactivation of genes encoded by chromosome 3p . The Journal of Clinical Investigation . 83 . 6 . 2120–2124 . Jun 1989 . 2542383 . 303939 . 10.1172/JCI114125 .
• Mitta M, Kato I, Tsunasawa S . The nucleotide sequence of human aminoacylase-1 . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1174 . 2 . 201–3 . Aug 1993 . 8357837 . 10.1016/0167-4781(93)90116-u .
• Cook RM, Burke BJ, Buchhagen DL, Minna JD, Miller YE . Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer . The Journal of Biological Chemistry . 268 . 23 . 17010–7 . Aug 1993 . 10.1016/S0021-9258(19)85294-8 . 8394326 . free .
• Lindner HA, Lunin VV, Alary A, Hecker R, Cygler M, Ménard R . Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family . The Journal of Biological Chemistry . 278 . 45 . 44496–44504 . Nov 2003 . 12933810 . 10.1074/jbc.M304233200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Van Coster RN, Gerlo EA, Giardina TG, Engelke UF, Smet JE, De Praeter CM, Meersschaut VA, De Meirleir LJ, Seneca SH, Devreese B, Leroy JG, Herga S, Perrier JP, Wevers RA, Lissens W . Aminoacylase I deficiency: a novel inborn error of metabolism . Biochemical and Biophysical Research Communications . 338 . 3 . 1322–1326 . Dec 2005 . 16274666 . 10.1016/j.bbrc.2005.10.126 .
• Sass JO, Mohr V, Olbrich H, Engelke U, Horvath J, Fliegauf M, Loges NT, Schweitzer-Krantz S, Moebus R, Weiler P, Kispert A, Superti-Furga A, Wevers RA, Omran H . Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism . American Journal of Human Genetics . 78 . 3 . 401–409 . Mar 2006 . 16465618 . 1380284 . 10.1086/500563 .
• Figueiredo EL, Garcia Leão FV, De Oliveira LV, Moreira Mda C, De Souza Figueiredo AF . The amidase activity of human tissue kallikrein is significantly lower in the urine of patients with systolic heart failure . Journal of Cardiac Failure . 12 . 8 . 653–658 . Oct 2006 . 17045186 . 10.1016/j.cardfail.2006.06.004 .

Notes and References

1. Miller YE, Drabkin H, Jones C, Fisher JH . Human aminoacylase-1: cloning, regional assignment to distal chromosome 3p21.1, and identification of a cross-hybridizing sequence on chromosome 18 . Genomics . 8 . 1 . 149–154 . Sep 1990 . 1707030 . 10.1016/0888-7543(90)90237-O .
2. Voss R, Lerer I, Povey S, Solomon E, Bobrow M . Confirmation and further regional assignment of aminoacylase 1 (acy-1) on human chromosome 3 using a simplified detection method . Annals of Human Genetics . 44 . Pt 1 . 1–9 . Jul 1980 . 6948533 . 10.1111/j.1469-1809.1980.tb00940.x . 21566170 .
3. Web site: Entrez Gene: ACY1 aminoacylase 1.