Amino acid transporter explained

Symbol:Aa_trans
Transmembrane amino acid transporter protein
Pfam:PF01490
Interpro:IPR013057
Tcdb:2.A.18
Membranome Superfamily:228

An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.

Families

There are several families that function in amino acid transport, some of these include:

Solute carrier family examples

VIAAT

Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.[13]

Human proteins containing this domain

SLC32A1

SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6.

See also

Notes and References

  1. Kanai Y, Hediger MA. The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects. Pflügers Arch . 447 . 5 . 469–479 . 2004. 10.1007/s00424-003-1146-4 . 14530974. 21564906.
  2. Palacin M, Kanai Y. The ancillary proteins of HATs: SLC3 family of amino acid transporters. Pflügers Arch . 447 . 5 . 490–494 . 2004. 10.1007/s00424-003-1062-7 . 14770309. 25808108.
  3. Singh SK, Piscitelli CL, Yamashita A, Gouaux E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science . 322 . 5908 . 1655–1661 . 2008. 10.1126/science.1166777 . 19074341 . 2832577. 2008Sci...322.1655S.
  4. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y . CATs and HATs: the SLC7 family of amino acid transporters . Pflügers Arch . 447 . 5 . 532–542 . 2004 . 10.1007/s00424-003-1086-z . 14770310. 11670040 .
  5. Daniel H, Kottra G . The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology . Pflügers Arch . 447 . 5 . 610–618 . 2004 . 10.1007/s00424-003-1101-4 . 12905028. 22369521 .
  6. Reimer RJ, Edwards RH . Organic anion transport is the primary function of the SLC17/type I phosphate transporter family . Pflügers Arch . 447 . 5 . 629–635 . 2004 . 10.1007/s00424-003-1087-y . 12811560. 9680597 .
  7. Eiden LE, Schafer MK, Weihe E, Schutz B . The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine . Pflügers Arch . 447 . 5 . 636–640 . 2004 . 10.1007/s00424-003-1100-5 . 12827358. 20764857 .
  8. Palmieri F . The mitochondrial transporter family (SLC25): physiological and pathological implications . Pflügers Arch . 447 . 5 . 689–709 . 2004 . 10.1007/s00424-003-1099-7 . 14598172. 25304722 .
  9. Mount DB, Romero MF . The SLC26 gene family of multifunctional anion exchangers . Pflügers Arch . 447 . 5 . 710–721 . 2004 . 10.1007/s00424-003-1090-3 . 12759755. 20302398 .
  10. Gasnier B . The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids . Pflügers Arch . 447 . 5 . 752–755 . 2004 . 10.1007/s00424-003-1091-2 . 12750892. 24669893 .
  11. Boll M, Daniel H, Gasnier B . The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family . Pflügers Arch . 447 . 5 . 776–779 . 2004 . 10.1007/s00424-003-1073-4 . 12748860. 25655241 .
  12. Mackenzie B, Erickson JD . Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family . Pflügers Arch . 447 . 5 . 784–795 . 2004 . 10.1007/s00424-003-1117-9 . 12845534. 35457147 .
  13. Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in TC6 Cells, Mouse Clonal -Cells, and -Cells of Islets of Langerhans

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