Althiomycin Explained

Althiomycin (matamycin) is a thiazole antibiotic, effective against Gram-positive and Gram-negative bacteria. The name matamycin is from "Mata Hari"[1] and the suffix .

Isolated from Streptomyces matensis, the compound was first described by Margalith et al. in 1959.[2] It acts a protein synthesis inhibitor and its site of action is the 50S subunit of the bacterial ribosome.

Notes and References

  1. Aronson J . That's show business . BMJ (Clinical Research Ed.) . 319 . 7215 . 972 . October 1999 . 10514162 . 1116803 . 10.1136/bmj.319.7215.972.
  2. Book: Pestka S . Mechanism of Action of Antimicrobial and Antitumor Agents. Antibiotics . Althiomycin . Corcoran JW, Hahn FE, Snell JF, Arora KL . 10.1007/978-3-642-46304-4_21 . Berlin Heidelberg . Springer-Verlag . 1975 . 323–6 . 978-3-642-46304-4 .

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