Alternative-complement-pathway C3/C5 convertase explained

Alternative-complement-pathway C3/C5 convertase
Ec Number:	3.4.21.47
Cas Number:	80295-67-6

Alternative-complement-pathway C3/C5 convertase (complement component C3/C5 convertase (alternative), proenzyme factor B, properdin factor B, C3 proactivator, glycine-rich beta-glycoprotein, heat-labile factor, C3 convertase, C3b,Bb,CVF,Bb,C5 convertase, (C3b)n,Bb, complement C 3(C 5) convertase (amplification), alternative complement pathway C3(C5) convertase, C5 convertase, CVF,Bb, (CVF)-dependent glycine-rich-beta-glucoprotein, cobra venom factor-dependent C3 convertase) is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg- bond in complement component C5 alpha-chain to yield C5a and C5b

This enzyme is a bimolecular complex of complement fragment Bb with either C3b or cobra venom factor.

See also

• Alternative complement pathway

Notes and References

1. Book: Kerr MA . Human factor B . [8] Human factor B . Methods in Enzymology . 80 Pt C . 102–12 . 1981 . 7043188 . 10.1016/s0076-6879(81)80010-9 . 9780121819804 .
2. Morley BJ, Campbell RD . Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen . The EMBO Journal . 3 . 1 . 153–7 . January 1984 . 6323161 . 557312 . 10.1002/j.1460-2075.1984.tb01776.x.
3. Müller-Eberhard HJ . Molecular organization and function of the complement system . Annual Review of Biochemistry . 57 . 321–47 . 1988 . 3052276 . 10.1146/annurev.bi.57.070188.001541 .