Alternariol Explained

Alternariol is a toxic metabolite of Alternaria fungi.[1] It is an important contaminant in cereals and fruits.[2] Alternariol exhibits antifungal and phytotoxic activity. It is reported to inhibit cholinesterase enzymes.[3] It is also a mycoestrogen.

A 2017 in vitro assay study reported alternariol to be a full androgen agonist.[4]

Notes and References

  1. Davis VM, Stack ME . Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium . Appl. Environ. Microbiol. . 60 . 10 . 3901–2 . 1 October 1994. 10.1128/AEM.60.10.3901-3902.1994 . 7986060 . 201908 . 1994ApEnM..60.3901D .
  2. Brugger EM, Wagner J, Schumacher DM . Mutagenicity of the mycotoxin alternariol in cultured mammalian cells . Toxicol. Lett. . 164 . 3 . 221–30 . 2006 . 16464542 . 10.1016/j.toxlet.2006.01.001. etal.
  3. http://www.fermentek.com/Alternariol Alternariol
  4. Stypuła-Trębas. Sylwia. Minta. Maria. Radko. Lidia. Jedziniak. Piotr. Posyniak. Andrzej. Nonsteroidal mycotoxin alternariol is a full androgen agonist in the yeast reporter androgen bioassay. Environmental Toxicology and Pharmacology. 55. 2017. 208–211. 1382-6689. 10.1016/j.etap.2017.08.036. 28910742.

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