Altemicidin Explained

Altemicidin is monoterpene alkaloid first identified in isolates from marine actinomycetes (specifically Streptomyces sioyaensis) in 1989.[1] [2] It may also be produced synthetically.[3] [4] Altemicidin displays both acaricidal and antitumor activity.[1]

Notes and References

  1. Takahashi. Atsushi. Kurasawa. Shogo. Ikeda. Daishiro. Okami. Yoshiro. Takeuchi. Tomio. Altemicidin, a new acaricidal and antitumor substance. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.. The Journal of Antibiotics. 42. 11. 1989. 1556–1561. 0021-8820. 10.7164/antibiotics.42.1556. free. 2584137 .
  2. Takahashi. Atsushi. Ikeda. Daishiro. Nakamura. Hikaru. Naganawa. Hiroshi. Kurasawa. Shogo. Okami. Yoshiro. Takeuchi. Tomio. Iitaka. Yoichi. Altemicidin, a new acaricidal and antitumor substance. II. Structure determination.. The Journal of Antibiotics. 42. 11. 1989. 1562–1566. 0021-8820. 10.7164/antibiotics.42.1562. free. 2584138 .
  3. Kende. Andrew S.. Liu. Kun. Jos Brands. K. M.. Total Synthesis of (-)-Altemicidin: A Novel Exploitation of the Potier-Polonovski Rearrangement. Journal of the American Chemical Society. 117. 42. 1995. 10597–10598. 0002-7863. 10.1021/ja00147a032.
  4. Kan. Toshiyuki. Kawamoto. Yuichiro. Asakawa. Tomohiro. Furuta. Takumi. Fukuyama. Tohru. Synthetic Studies on Altemicidin: Stereocontrolled Construction of the Core Framework. Organic Letters. 10. 2. 2008. 169–171. 1523-7060. 10.1021/ol701940f. 18081299.

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