Α-Cadinol Explained

α-Cadinol or 10α-hydroxy-4-cadinene is an organic compound, a sesquiterpenoid alcohol.^{[1] [2]}

Natural occurrence

This compound is found in essential oils and extracts of many plants, such as

• Agrotaxis selaginoides,
• Tabernaemontana catharinensis^[3]
• Litsea acutivena (7.7%),^[4]
• Salvia aratocensis (20%),^[5]
• Protium giganteum (7%),^[6]
• Uvaria ovata root bark (13–24%),^[7]
• Plinia trunciflora (19%)^[8]
• Tanacetum sonbolii (35%)^[9]
• Schisandra chinensis berries (5%),^[10]
• Melia azedarach (11%),^[11]
• Neolitsea parvigemma (10%),^[12]
• Tetradenia riparia (8%)^[13]

Biological activity

α-Cadinol was said to act as anti-fungal^[12] and as hepatoprotective,^[14] and was proposed as a possible remedy for drug-resistant tuberculosis.^[5]

See also

• δ-Cadinol (torreyol)

Notes and References

1. 10.1016/S0040-4020(01)92031-9 . Configurations and conformations of torreyol (δ-cadinol), α-cadinol, T-muurolol and T-cadinol . 1981 . Borg-Karlson . A . Tetrahedron . 37 . 22 . 425–430.
2. V. Herout . V. Sýkora . 1958 . The chemistry of cadinenes and cadinols . Tetrahedron . 4 . 246–255 . 10.1016/0040-4020(58)80046-0 . 3–4.
3. 22273350 . 2012 . Boligon . AA . Schwanz . TG . Piana . M . Bandeira . RV . Frohlich . JK . Brum . TF . Zadra . M . Athayde . ML . Chemical composition and antioxidant activity of the essential oil of Tabernaemontana catharinensis A. DC. Leaves . 10.1080/14786419.2011.653971 . Natural Product Research . 68–71 . 27. 1 . 2230969 .
4. 22224304 . 2011 . Ho . CL . Liao . PC . Wang . EI . Su . YC . Composition and antimicrobial activity of the leaf and twig oils of Litsea acutivena from Taiwan . 6 . 11 . 1755–8 . Natural Product Communications. 10.1177/1934578X1100601145. free .
5. 22224302 . 2011 . Bueno . J . Escobar . P . Martínez . JR . Leal . SM . Stashenko . EE . Composition of three essential oils, and their mammalian cell toxicity and antimycobacterial activity against drug resistant-tuberculosis and nontuberculous mycobacteria strains . 6 . 11 . 1743–8 . Natural Product Communications. 10.1177/1934578X1100601143 . 30506397 . free .
6. 22224298 . 2011 . De Freitas . JG . Da Camara . CA . De Moraes . MM . Da Silva . HC . Volatile constituents of two species of Protium from the Atlantic rainforest in the state of Pernambuco, Brazil . 6 . 11 . 1727–30 . Natural Product Communications.
7. 22224295 . 2011 . Muriel . KA . Félix . TZ . Figueredo . G . Chalard . P . n'Guessan . YT . Essential oil of three Uvaria species from Ivory Coast . 6 . 11 . 1715–8 . Natural Product Communications. 10.1177/1934578X1100601136 . 23664205 . free .
8. 22117172 . 2011 . Lago . JH . Souza . ED . Mariane . B . Pascon . R . Vallim . MA . Martins . RC . Baroli . AA . Carvalho . BA . Soares . MG . 8. Chemical and biological evaluation of essential oils from two species of Myrtaceae - Eugenia uniflora L. And Plinia trunciflora (O. Berg) Kausel . 16 . 12 . 9827–37 . 6264170 . 10.3390/molecules16129827 . Molecules (Basel, Switzerland). free .
9. 22115413 . 2011 . Firozy . M . Talebpour . Z . Sonboli . A . Essential oil composition and antioxidant activities of the various extracts of Tanacetum sonbolii Mozaff. (Asteraceae) from Iran . 10.1080/14786419.2011.636746 . Natural Product Research . 2204–2207 . 26. 23 . 36405031 .
10. 22103398 . 2011 . Liu . CJ . Zhang . SQ . Zhang . JS . Liang . Q . Li . DS . Chemical composition and antioxidant activity of essential oil from berries of Schisandra chinensis (Turcz.) Baill . 10.1080/14786419.2011.636745 . Natural Product Research . 2199–2203 . 26. 23 . 12460120 .
11. 22063551 . 2011 . Yang . Y . Xiao . Y . Liu . B . Fang . X . Yang . W . Xu . J . Comparison of headspace solid-phase microextraction with conventional extraction for the analysis of the volatile components in Melia azedarach . 86 . 356–61 . 10.1016/j.talanta.2011.09.028 . Talanta.
12. 21941915 . 2011 . Ho . CL . Liao . PC . Wang . EI . Su . YC . Composition and antifungal activities of the leaf essential oil of Neolitsea parvigemma from Taiwan . 6 . 9 . 1357–60 . Natural Product Communications.
13. Z. C. Gazim . A. C. Amorim . A. M. Hovell . C. M. Rezende . I. A. Nascimento . G. A. Ferreira . D. A. Cortez . 2010 . Seasonal variation, chemical composition, and analgesic and antimicrobial activities of the essential oil from leaves of Tetradenia riparia (Hochst.) Codd in southern Brazil . Molecules . 15 . 8 . 5509–5524 . 6257709. 10.3390/molecules15085509 . 20714310. free .
14. Tung . Y. T. . Huang . C. C. . Ho . S. T. . Kuo . Y. H. . Lin . C. C. . Lin . C. T. . Wu . J. H. . 2011 . Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis in mice . J. Agric. Food Chem. . 59 . 15 . 8117–8123 . 10.1080/10412905.1999.9712005 . 21699244 .