Allylglycine Explained

Allylglycine is a glycine derivative. It is an inhibitor of glutamate decarboxylase.[1] Inhibition of glutamate decarboxylase blocks GABA biosynthesis, leading to lower levels of the neurotransmitter.[2] Allylglycine is known to induce seizures in animals studies, presumably due to this GDC-inhibiting activity.[3]

See also

Notes and References

  1. Abshire VM, Hankins KD, Roehr KE, DiMicco JA . Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate . Neuropharmacology . 27 . 11 . 1171–7 . November 1988 . 3205383 . 10.1016/0028-3908(88)90013-5. 32655173 .
  2. Sajdyk T, Johnson P, Fitz S, Shekhar A . Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior . J. Psychopharmacol. (Oxford) . 22 . 6 . 633–41 . August 2008 . 18308797 . 10.1177/0269881107082902 . 3065212.
  3. Thomas J, Yang YC . Allylglycine induced seizures in male and female rats . Physiol. Behav. . 49 . 6 . 1181–3 . June 1991 . 1654571. 10.1016/0031-9384(91)90348-R . 10506822 .

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