Allopregnanediol Explained

Allopregnanediol, or 5α-pregnane-3α,20α-diol, is an endogenous metabolite of progesterone and allopregnanolone and an isomer of pregnanediol (5β-pregnan-3α,20α-diol).[1] It has been found to act like a partial agonist of an allosteric site of the GABA receptor and hence might play a biological role as a neurosteroid.[2] It has also been found to act as an agonist of the human pregnane X receptor, albeit with an EC50 that is more than an order of magnitude lower than that of other endogenous pregnanes like pregnenolone, pregnanediol, allopregnanedione, and allopregnanolone.[3]

Chemistry

See also: List of neurosteroids.

Notes and References

  1. Book: Finn. Deborah A.. Purdy. Robert H.. Handbook of Contemporary Neuropharmacology. Neuroactive Steroids in Anxiety and Stress. 2007. 10.1002/9780470101001.hcn026. 978-0470101001.
  2. Belelli D, Gee KW . 5 alpha-pregnan-3 alpha,20 alpha-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneurosomes . Eur. J. Pharmacol. . 167 . 1 . 173–6 . 1989 . 2550257 . 10.1016/0014-2999(89)90760-7.
  3. Ekins. Sean. Reschly. Erica J. Hagey. Lee R. Krasowski. Matthew D. Evolution of pharmacologic specificity in the pregnane X receptor. BMC Evolutionary Biology. 8. 1. 2008. 103. 1471-2148. 10.1186/1471-2148-8-103. 18384689. 2358886 . 2008BMCEE...8..103E . free .

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