Allene oxide cyclase explained

allene-oxide cyclase
Ec Number:	5.3.99.6
Cas Number:	118390-59-3
Go Code:	0046423

In enzymology, an allene-oxide cyclase is an enzyme that belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductases. The systematic name of this enzyme class is (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing).

The allene oxide of linolenic acid (i.e., (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate) is converted by allene oxide cyclase to jasmonic acid ((15Z)-12-oxophyto-10,15-dienoate).^[1]

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes,,,,, and .

References

• Hamberg M . Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase . Biochemical and Biophysical Research Communications . 156 . 1 . 543–50 . October 1988 . 3178850 . 10.1016/S0006-291X(88)80876-3 .

Notes and References

1. Schaller A, Stintzi A . Enzymes in jasmonate biosynthesis - structure, function, regulation . Phytochemistry . 70 . 13–14 . 1532–8 . September 2009 . 19703696 . 10.1016/j.phytochem.2009.07.032 .