Alkylglycerone phosphate synthase explained

alkylglycerone-phosphate synthase
Ec Number:	2.5.1.26
Cas Number:	64060-42-0
Go Code:	0008609

Alkylglycerone phosphate synthase (alkyldihydroxyacetonephosphate synthase, alkyldihydroxyacetone phosphate synthetase, alkyl DHAP synthetase, alkyl-DHAP, dihydroxyacetone-phosphate acyltransferase, DHAP-AT) is an enzyme associated with Type 3 Rhizomelic chondrodysplasia punctata.^{[1] [2]} This enzyme catalyses the following chemical reaction

1-acyl-glycerone 3-phosphate + a long-chain alcohol

\rightleftharpoons an alkyl-glycerone 3-phosphate + a long-chain acid anion

Notes and References

1. Brown AJ, Snyder F . Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism . The Journal of Biological Chemistry . 257 . 15 . 8835–9 . August 1982 . 10.1016/S0021-9258(18)34205-4 . 7096336 . free .
2. Wykle RL, Plantadosi C, Snyder F . The role of acyldihydroxyacetone phosphate, reduced nicotinamide adenine dinucleotide, and reduced nicotinamide adenine dinucleotide phosphate in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor . The Journal of Biological Chemistry . 247 . 9 . 2944–8 . May 1972 . 10.1016/S0021-9258(19)45301-5 . 4401994 . free .