Aliphatic aldoxime dehydratase explained

Aliphatic aldoxime dehydratase
Ec Number:	4.99.1.5

In enzymology, an aliphatic aldoxime dehydratase is an enzyme that catalyzes the chemical reaction

an aliphatic aldoxime

\rightleftharpoons an aliphatic nitrile + H₂O

This dehydratase converts an aldoxime on an aliphatic substrate to a nitrile as the product structure with water as byproduct.

This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that do not fit into any other sub-class. The systematic name of this enzyme class is aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming). Other names in common use include OxdA, and aliphatic aldoxime hydro-lyase.

See also

• D-amino acid oxidase, sometimes also referred to as OXDA

References

• Kobayashi M . 2003 . Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23. Sequencing, gene expression, purification, and characterization . J. Biol. Chem. . 278 . 29600 - 8 . 12773527 . 10.1074/jbc.M211832200 . Hashimoto . Y . Konishi . K . Goda . M . Noguchi . T . Higashibata . H . Kobayashi . M . 32 . free .
• Xie SX, Kato Y, Komeda H, Yoshida S, Asano Y . 2003 . A gene cluster responsible for alkylaldoxime metabolism coexisting with nitrile hydratase and amidase in Rhodococcus globerulus A-4 . Biochemistry . 42 . 12056 - 66 . 14556637 . 10.1021/bi035092u . 41 . 10.1.1.513.2481 .
• Kato Y, Yoshida S, Xie SX, Asano Y . 2004 . Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. N-771 . J. Biosci. Bioeng. . 97 . 250 - 9 . 16233624 . 4 . 10.1016/S1389-1723(04)70200-5 .