Aldehyde dehydrogenase (NADP+) explained

Aldehyde dehydrogenase (NADP+)
Ec Number:	1.2.1.4
Cas Number:	9028-87-9

In enzymology, an aldehyde dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction

an aldehyde + NADP⁺ + H₂O

\rightleftharpoons an acid + NADPH + H⁺

The 3 substrates of this enzyme are aldehyde, NADP⁺, and H₂O, whereas its 3 products are acid, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aldehyde:NADP+ oxidoreductase. Other names in common use include NADP+-acetaldehyde dehydrogenase, NADP+-dependent aldehyde dehydrogenase, and aldehyde dehydrogenase (NADP+). This enzyme participates in caprolactam degradation.

References

• Adachi O, Matsushita K, Shinagawa E, Ameyama M . 1980 . Crystallization and properties of NADP-dependent aldehyde dehydrogenase from Gluconobacter melanogenus . Agric. Biol. Chem. . 44 . 155 - 164 . 10.1271/bbb1961.44.155. free .
• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
• Nakayama T . Tokyo . Acetic acid bacteria. II. Intracellular distribution of enzymes related to acetic acid fermentation, and some properties of a highly purified triphosphopyridine nucleotide (TPN)-dependent aldehyde dehydrogenase . J. . Biochem. . 812 - 830 .
• SEEGMILLER JE . 1953 . Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast . J. Biol. Chem. . 201 . 629 - 37 . 13061400 . 2 .