Aldehyde dehydrogenase (NAD(P)+) explained

aldehyde dehydrogenase [NAD(P)+]
Ec Number:	1.2.1.5
Cas Number:	9028-88-0
Go Code:	0004030

In enzymology, an aldehyde dehydrogenase [NAD(P)+] is an enzyme that catalyzes the chemical reaction

an aldehyde + NAD(P)+ + H₂O

\rightleftharpoons an acid + NAD(P)H + H⁺

The 4 substrates of this enzyme are aldehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are acid, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aldehyde:NAD(P)+ oxidoreductase. Other names in common use include aldehyde dehydrogenase [NAD(P)+], and ALDH. This enzyme participates in 5 metabolic pathways: glycolysis / gluconeogenesis, histidine metabolism, tyrosine metabolism, phenylalanine metabolism, and metabolism of xenobiotics by cytochrome p450.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

References

• Black S . 1951 . Yeast aldehyde dehydrogenase . Arch. Biochem. Biophys. . 34 . 86 - 97 . 10.1016/S0003-9861(51)80013-4 . 14904038 . 1 .
• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
• KING TE, CHELDELIN VH . 1956 . Oxidation of acetaldehyde by Acetobacter suboxydans . J. Biol. Chem. . 220 . 177 - 91 . 13319337 . 1 .
• Steinman CR, Jakoby WB . 1967 . Yeast aldehyde dehydrogenase. I. Purification and crystallization . J. Biol. Chem. . 242 . 5019 - 23 . 4293780 . 21 .
• Tanenbaum SW . 1956 . The metabolism of Acetobacter peroxidans. I. Oxidative enzymes . Biochim. Biophys. Acta . 21 . 2 . 335 - 342 . 10.1016/0006-3002(56)90017-8 . 13363916 .