Alcohol dehydrogenase (quinone) explained

Alcohol dehydrogenase (quinone)
Ec Number:1.1.5.5

Alcohol dehydrogenase (quinone) (type III ADH, membrane associated quinohaemoprotein alcohol dehydrogenase) is an enzyme with systematic name alcohol:quinone oxidoreductase.[1] [2] [3] [4] [5] [6] [7] [8] [9] This enzyme catalyses the following chemical reaction

ethanol + ubiquinone

\rightleftharpoons

acetaldehyde + ubiquinol

This enzyme is present in acetic acid bacteria where it is involved in acetic acid production.

Notes and References

  1. Gómez-Manzo S, Contreras-Zentella M, González-Valdez A, Sosa-Torres M, Arreguín-Espinoza R, Escamilla-Marván E . The PQQ-alcohol dehydrogenase of Gluconacetobacter diazotrophicus . International Journal of Food Microbiology . 125 . 1 . 71–8 . June 2008 . 18321602 . 10.1016/j.ijfoodmicro.2007.10.015 .
  2. Shinagawa E, Toyama H, Matsushita K, Tuitemwong P, Theeragool G, Adachi O . A novel type of formaldehyde-oxidizing enzyme from the membrane of Acetobacter sp. SKU 14 . Bioscience, Biotechnology, and Biochemistry . 70 . 4 . 850–7 . April 2006 . 16636451 . 10.1271/bbb.70.850 . free .
  3. Chinnawirotpisan P, Theeragool G, Limtong S, Toyama H, Adachi OO, Matsushita K . Quinoprotein alcohol dehydrogenase is involved in catabolic acetate production, while NAD-dependent alcohol dehydrogenase in ethanol assimilation in Acetobacter pasteurianus SKU1108 . Journal of Bioscience and Bioengineering . 96 . 6 . 564–71 . 2003 . 16233574 . 10.1016/S1389-1723(04)70150-4 .
  4. Frébortova J, Matsushita K, Arata H, Adachi O . Intramolecular electron transport in quinoprotein alcohol dehydrogenase of Acetobacter methanolicus: a redox-titration study . Biochimica et Biophysica Acta (BBA) - Bioenergetics . 1363 . 1 . 24–34 . January 1998 . 9526036 . 10.1016/s0005-2728(97)00090-x .
  5. Matsushita K, Kobayashi Y, Mizuguchi M, Toyama H, Adachi O, Sakamoto K, Miyoshi H . A tightly bound quinone functions in the ubiquinone reaction sites of quinoprotein alcohol dehydrogenase of an acetic acid bacterium, Gluconobacter suboxydans . Bioscience, Biotechnology, and Biochemistry . 72 . 10 . 2723–31 . October 2008 . 18838797 . 10.1271/bbb.80363 . 23975228 . https://web.archive.org/web/20190228041354/http://pdfs.semanticscholar.org/8c12/a230a02249e6968b537545eef62b1e15ba7e.pdf . dead . 2019-02-28 .
  6. Matsushita K, Yakushi T, Toyama H, Shinagawa E, Adachi O . Function of multiple heme c moieties in intramolecular electron transport and ubiquinone reduction in the quinohemoprotein alcohol dehydrogenase-cytochrome c complex of Gluconobacter suboxydans . The Journal of Biological Chemistry . 271 . 9 . 4850–7 . March 1996 . 8617755 . 10.1074/jbc.271.9.4850 . free .
  7. Ethanol oxidase respiratory chain of acetic acid bacteria. Reactivity with ubiquinone of pyrroloquinoline quinone-dependent alcohol dehydrogenases purified from Acetobacter aceti and Gluconobacter suboxydans . Biosci. Biotechnol. Biochem. . 56 . 2 . 304–310 . 1992 . 27823530 . 10.1271/bbb.56.304 . Matsushita . Kazunobu . Takaki . Yoshihiro . Shinagawa . Emiko . Ameyama . Minoru . Adachi . Osao . free .
  8. Matsushita K, Toyama H, Adachi O . Respiratory chains and bioenergetics of acetic acid bacteria . Advances in Microbial Physiology . 36 . 247–301 . 1994 . 7942316 . 10.1016/s0065-2911(08)60181-2 . 9780120277360 .
  9. Cozier GE, Giles IG, Anthony C . The structure of the quinoprotein alcohol dehydrogenase of Acetobacter aceti modelled on that of methanol dehydrogenase from Methylobacterium extorquens . The Biochemical Journal . 308 (Pt 2) . 2 . 375–9 . June 1995 . 7772016 . 1136936 . 10.1042/bj3080375 .

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