Alanopine dehydrogenase explained

alanopine dehydrogenase
Ec Number:	1.5.1.17
Cas Number:	71343-07-2
Go Code:	0047636

Alanopine dehydrogenase is an enzyme that catalyzes the chemical reaction

2,2'-iminodipropanoate + NAD⁺ + H₂O

\rightleftharpoons L-alanine + pyruvate + NADH + H⁺

The 2 substrates of this enzyme are 2,2'-iminodipropanoate, and nicotinamide adenine dinucleotide+. water is excluded since water is 55M and does not change. Its 4 products are L-alanine, pyruvate, nicotinamide adenine dinucleotide, and hydrogen ion.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming). Other names in common use include ALPDH, alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase, meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase, alanopine: NAD+ oxidoreductase, ADH, and alanopine:NAD+ oxidoreductase.

References

• Dando PR . 1981 . Strombine [N-(carboxymethyl)-D-alanine] dehydrogenase and alanopine [meso-N-(1-carboxyethyl)-alanine]dehydrogenase from the mussel Mytilus edulis L . Biochem. Soc. Trans. . 9 . 297 - 298 .
• Fields JH, Eng AK, Ramsden WD, Hochachka PW, Weinstein B . 1980 . Alanopine and strombine are novel imino acids produced by a dehydrogenase found in the adductor muscle of the oyster, Crassostrea gigas . Arch. Biochem. Biophys. . 201 . 110 - 4 . 6156653 . 10.1016/0003-9861(80)90493-2 . 1 .
• Fields JH, Hochachka PW . 1981 . Purification and properties of alanopine dehydrogenase from the adductor muscle of the oyster, Crassostrea gigas (Mollusca, Bivalvia) . Eur. J. Biochem. . 114 . 615 - 21 . 7238503 . 10.1111/j.1432-1033.1981.tb05188.x . 3 . free .