Molybdopterin-synthase adenylyltransferase explained

Molybdopterin-synthase adenylyltransferase
Ec Number:	2.7.7.80

Molybdopterin-synthase adenylyltransferase (MoeB, adenylyltransferase and sulfurtransferase MOCS3) is an enzyme with systematic name ATP:molybdopterin-synthase adenylyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly

\rightleftharpoons diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP

This enzyme adenylates the C-terminus of the small subunit of the molybdopterin synthase.

Notes and References

1. Leimkühler S, Wuebbens MM, Rajagopalan KV . Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor . The Journal of Biological Chemistry . 276 . 37 . 34695–701 . September 2001 . 11463785 . 10.1074/jbc.M102787200 . free .
2. Matthies A, Nimtz M, Leimkühler S . Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry . Biochemistry . 44 . 21 . 7912–20 . May 2005 . 15910006 . 10.1021/bi0503448 .