Adenovirus vaccine explained

Type:vaccine
Target:Adenovirus
Vaccine Type:Live virus
Dailymedid:Adenovirus type
Routes Of Administration:Oral administration
Atc Prefix:None
Legal Us:Rx-only
Legal Us Comment:[1] [2]
Drugbank:DB14409
Unii:FKD3DUK39I
Unii2:TM54L796SN

An adenovirus vaccine is a vaccine against adenovirus infection.[3] According to American CDC, "There is currently no adenovirus vaccine available to the general public.[4]

It should not be confused with the strategy of using adenovirus as a viral vector to develop vaccines for other pathogens, or as a general gene carrier.[5] [6] [7]

US military

It was used by the United States military from 1971 to 1999, but was discontinued when the only manufacturer stopped production.[8] [9] This vaccine elicited immunity to adenovirus serotypes 4 and 7,[10] the serotypes most often associated with acute respiratory disease. On 16 March 2011, the U.S. Food and Drug Administration approved an adenovirus vaccine manufactured by Teva Pharmaceuticals under contract to the U.S. Army.[11] This vaccine is essentially the same as the one used from 1971 to 1999. On 24 October 2011, the military services began administering the new adenovirus vaccine to recruits during basic training.[12]

The vaccine is orally administered and consists of live (not attenuated) virus. The tablets are coated, so that the virus passes the stomach and infects the intestines, where the immune response is raised.[13]

External links

Notes and References

  1. Web site: Adenovirus Type 4 and Type 7 Vaccine, Live kit . DailyMed . 26 July 2022 . 8 September 2023.
  2. Web site: Adenovirus Type 4 and Type 7 Vaccine, Live, Oral . U.S. Food and Drug Administration (FDA) . 15 October 2019 . 8 September 2023 . STN: BL 125296 .
  3. Tucker SN, Tingley DW, Scallan CD . Oral adenoviral-based vaccines: historical perspective and future opportunity . Expert Rev Vaccines . 7 . 1 . 25–31 . February 2008. 18251691 . 10.1586/14760584.7.1.25 . 7058518 .
  4. Web site: 2023-04-27 . Adenovirus Vaccine Information Statement CDC . 2023-10-30 . www.cdc.gov . en-us.
  5. etal . Croyle MA, Patel A, Tran KN . 2008 . Doolan . Denise L. . Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice . PLOS ONE . 3 . 10 . e3548 . 2008PLoSO...3.3548C . 10.1371/journal.pone.0003548 . 2569416 . 18958172 . free.
  6. Hartman ZC, Appledorn DM, Amalfitano A . March 2008 . Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications . Virus Res. . 132 . 1–2 . 1–14 . 10.1016/j.virusres.2007.10.005 . 4039020 . 18036698.
  7. Tatsis N, Ertl HC . October 2004 . Adenoviruses as vaccine vectors . Mol. Ther. . 10 . 4 . 616–29 . 10.1016/j.ymthe.2004.07.013 . 7106330 . 15451446 . free.
  8. Russell KL, Hawksworth AW, Ryan MA . Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999-2004 . Vaccine . 24 . 15 . 2835–42 . April 2006. 16480793 . 1955759 . 10.1016/j.vaccine.2005.12.062 . etal.
  9. Web site: Vaccine Trials For "Boot Camp Crud" May Help 20 Percent of Recruits . 15 January 2009. https://web.archive.org/web/20090212011026/http://www.navy.mil/search/display.asp?story_id=26369. 12 February 2009 . live.
  10. Two fatal cases of adenovirus-related illness in previously healthy young adults--Illinois, 2000 . MMWR Morb. Mortal. Wkly. Rep. . 50 . 26 . 553–5 . July 2001. 11456329 . Centers for Disease Control and Prevention (CDC).
  11. Malarkey MA, Baylor NW. FDA approval letter dated 16 March 2011.
  12. Choudhry A, Mathena J, Albano JD, Yacovone M, Collins L . Safety evaluation of adenovirus type 4 and type 7 vaccine live, oral in military recruits. Vaccine. 34. 38. 4558–4564. 31 August 2016. 10.1016/j.vaccine.2016.07.033. 27475474. free.
  13. https://www.fda.gov/media/80211/download Package insert for Adenovirus Type 4 and Type 7 Vaccine, Live, Oral

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