Adenosylcobinamide-phosphate synthase explained

Adenosylcobinamide-phosphate synthase
Ec Number:	6.3.1.10
Cas Number:	905988-16-1

Adenosylcobinamide-phosphate synthase (CbiB) is an enzyme with systematic name adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

(1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate

\rightleftharpoons ADP + phosphate + adenosylcobinamide phosphate

(2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol

\rightleftharpoons ADP + phosphate + adenosylcobinamide

One of the substrates, (R)-1-aminopropan-2-yl phosphate, is produced by CobD . This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in bacteria.

See also

• Cobalamin biosynthesis

Notes and References

1. Cheong CG, Bauer CB, Brushaber KR, Escalante-Semerena JC, Rayment I . Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica . Biochemistry . 41 . 15 . 4798–808 . April 2002 . 11939774 . 10.1021/bi012111w . 10.1.1.564.9386 .
2. Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC . The biosynthesis of adenosylcobalamin (vitamin B12) . Natural Product Reports . 19 . 4 . 390–412 . August 2002 . 12195810 . 10.1039/b108967f .