Adapalene/benzoyl peroxide explained
| Verifiedfields: | changed |
| Watchedfields: | changed |
| Verifiedrevid: | 448240024 |
| Type: | combo |
| Component1: | Adapalene |
| Class1: | Retinoid |
| Component2: | Benzoyl peroxide |
| Class2: | Peroxide |
| Tradename: | Epiduo, Epiduo Forte |
| Routes Of Administration: | Topical |
| Atc Prefix: | D10 |
| Atc Suffix: | AD53 |
| Legal Us: | Rx-only |
| Legal Us Comment: | [1] [2] |
| Legal Status: | Rx-only |
| Cas Number: | 1194805-81-6 |
| Kegg: | D10792 |
Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of severe acne vulgaris. It consists of a combination of adapalene and benzoyl peroxide in a topical gel formulation.
It is available as a generic medication.[3]
Medical uses
Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.
Side effects
Commonly reported side effects include the following:
Research
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.[4]
The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied;[5] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
External links
Notes and References
- Web site: Epiduo- adapalene and benzoyl peroxide gel . DailyMed . 21 February 2018 . 15 May 2022.
- Web site: Epiduo Forte- adapalene and benzoyl peroxide gel . DailyMed . 27 April 2022 . 15 May 2022.
- Web site: Competitive Generic Therapy Approvals . U.S. Food and Drug Administration (FDA) . 29 June 2023 . 29 June 2023 . 29 June 2023 . https://web.archive.org/web/20230629233651/https://www.fda.gov/drugs/generic-drugs/competitive-generic-therapy-approvals . live .
- Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS . Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients . The Journal of Dermatological Treatment . 22 . 4 . 197–205 . August 2011 . 20666678 . 10.3109/09546631003681094 . 34631151 .
- Dréno B, Kaufmann R, Talarico S, Torres Lozada V, Rodríguez-Castellanos MA, Gómez-Flores M, De Maubeuge J, Berg M, Foley P, Sysa-Jedrzejowska A, Kerrouche N, Paliargues F, Bettoli V . 6 . Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study . The British Journal of Dermatology . 165 . 2 . 383–90 . August 2011 . 21495995 . 10.1111/j.1365-2133.2011.10374.x . 21793660 .
