Acyl-homoserine-lactone acylase explained

Acyl-homoserine-lactone acylase
Ec Number:	3.5.1.97

Acyl-homoserine-lactone acylase (acyl-homoserine lactone acylase, AHL-acylase, AiiD, N-acyl-homoserine lactone acylase, PA2385 protein, quorum-quenching AHL acylase, quorum-quenching enzyme, PvdQ, QuiP) is an enzyme with systematic name N-acyl-L-homoserine-lactone amidohydrolase.^{[1] [2]} This enzyme functions as a quorum quencher by catalysing the following chemical reaction

an N-acyl-L-homoserine lactone + H₂O

\rightleftharpoons L-homoserine lactone + a carboxylate

Acyl homoserine lactones (AHLs) are produced by a number of bacterial species .

Notes and References

1. Sio CF, Otten LG, Cool RH, Diggle SP, Braun PG, Bos R, Daykin M, Cámara M, Williams P, Quax WJ . Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1 . Infection and Immunity . 74 . 3 . 1673–82 . March 2006 . 16495538 . 1418629 . 10.1128/iai.74.3.1673-1682.2006 .
2. Lin YH, Xu JL, Hu J, Wang LH, Ong SL, Leadbetter JR, Zhang LH . Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes . Molecular Microbiology . 47 . 3 . 849–60 . February 2003 . 12535081 . 10.1046/j.1365-2958.2003.03351.x . free .