Acyl-CoA hydrolase explained

acyl-CoA hydrolase
Ec Number:3.1.2.20
Cas Number:37270-64-7
Go Code:0047617

The enzyme acyl-CoA hydrolase (EC 3.1.2.20) catalyzes the reaction

acyl-CoA + H2O

\rightleftharpoons

CoA + a carboxylate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acyl-CoA hydrolase. Other names in common use include acyl coenzyme A thioesterase, acyl-CoA thioesterase, acyl coenzyme A hydrolase, thioesterase B, thioesterase II, and acyl-CoA thioesterase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References