Acrylyl-CoA reductase (NADPH) explained

Acrylyl-CoA reductase (NADPH)
Ec Number:	1.3.1.84

Acrylyl-CoA reductase (NADPH) is an enzyme with systematic name propanoyl-CoA:NADP⁺ oxidoreductase.^{[1] [2]} This enzyme catalyses the following chemical reaction

propanoyl-CoA + NADP⁺

\rightleftharpoons acryloyl-CoA + NADPH + H⁺

This enzyme catalyses a step in the 3-hydroxypropionate/4-hydroxybutyrate cycle, an autotrophic CO₂ fixation pathway found in some Thermoacidophilic archaea.

Notes and References

1. Berg IA, Kockelkorn D, Buckel W, Fuchs G . A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea . Science . 318 . 5857 . 1782–6 . December 2007 . 18079405 . 10.1126/science.1149976 .
2. Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G . 3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales . Journal of Bacteriology . 191 . 14 . 4572–81 . July 2009 . 19429610 . 2704735 . 10.1128/JB.00068-09 .