Acropachy Explained
| Acropachy |
| Synonyms: | Thyroid acropachy |
Acropachy is a dermopathy associated with Graves' disease.[1] It is characterized by soft-tissue swelling of the hands and clubbing of the fingers. Radiographic imaging of affected extremities typically demonstrates periostitis, most commonly the metacarpal bones. The exact cause is unknown, but it is thought to be caused by stimulating auto-antibodies that are implicated in the pathophysiology of Graves' thyrotoxicosis. There is no effective treatment for acropachy.
Since it is closely associated with Graves' disease, it is associated with other manifestations of Graves' disease, such as Graves' ophthalmopathy[2] and thyroid dermopathy.[3]
Hereditary acropachy (also known as "isolated congenital nail clubbing") may be associated with HPGD.[4]
See also
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Notes and References
- Book: Chapter 55. Endocrine & Metabolic Disorders. In: CURRENT Rheumatology Diagnosis & Treatment, 3e.. Graf, Gratton. McGraw-Hill. 2013. New York, NY. Imboden . Hellmann . Stone.
- Fatourechi V, Bartley GB, Eghbali-Fatourechi GZ, Powell CC, Ahmed DD, Garrity JA . Graves' dermopathy and acropachy are markers of severe Graves' ophthalmopathy . Thyroid . 13 . 12 . 1141–4 . December 2003 . 14751035 . 10.1089/10507250360731541 .
- Fatourechi V, Ahmed DD, Schwartz KM . Thyroid acropachy: report of 40 patients treated at a single institution in a 26-year period . J. Clin. Endocrinol. Metab. . 87 . 12 . 5435–41 . December 2002 . 12466333 . 10.1210/jc.2002-020746. free .
- Tariq M, Azeem Z, Ali G, Chishti MS, Ahmad W . Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC) . J. Med. Genet. . 46 . 1 . 14–20 . January 2009 . 18805827 . 10.1136/jmg.2008.061234 .
