Acrocylindropepsin Explained

Acrocylindropepsin
Ec Number:3.4.23.28
Cas Number:37288-84-9

Acrocylindropepsin (Acrocylindrium proteinase, Acrocylindrium acid proteinase) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction

Preference for hydrophobic residues at P1 and P1'. Action on the B chain of insulin is generally similar to that of pepsin A, but it also cleaves Leu6-Cys(SO3H), Glu21-Arg and Asn3-Gln, although not Gln4-His

This enzyme is present in fungus Acrocylindrium sp.

Notes and References

  1. Purification and some properties of crystalline acid protease from Acrocylindrium sp . Uchino F, Kurono Y, Doi S . Agric. Biol. Chem. . 1967 . 31 . 428–434 . 10.1271/bbb1961.31.428. free .
  2. The specificity of acid proteinase from Acrocylindrium . Ichihara S, Uchino F . Agric. Biol. Chem. . 1975 . 39 . 423–428 . 10.1271/bbb1961.39.423. free .
  3. Takahashi K, Chang WJ . The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy) propane and pepstatin . Journal of Biochemistry . 80 . 3 . 497–506 . September 1976 . 10290 .

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