Superficial acral fibromyxoma explained

A superficial acral fibromyxoma is a type of myxoma and is a rare cutaneous condition characterized by a mesenchymal neoplasm that typically occurs on the digits of middle-aged adults.[1]

Signs and symptoms

Superficial acral fibromyxoma impacts the palm, heel, and ankle in addition to the acral regions, with a clear preference for the periungual and subungual regions of the fingers and toes.[2] It begins as a slow-growing, solitary nodule limited to the dermis and subcutaneous tissue, and it is typically painless.[3] They range in size from 0.6-5 cm.[4] Fifty percent of the cases involve the nails, exhibiting either onycholysis or hyperkeratosis.[5]

Causes

Although a precise cause has not been identified, history of trauma is uncommon and has been documented.[6]

Diagnosis

A histologic examination reveals stellate and spindled fibroblast-like cells proliferating moderately within a myxoid and/or collagenous matrix with prominent microvasculature.[7] There may be a hyperkeratotic overlaying epidermis.[8] [9] The tumor cells are distributed in a focally fascicular and loose storiform pattern.[4] This tumor can be positively stained with CD34, CD99, vimentin, and CD10.[7]

Differential diagnosis includes periungual and subungual fibroma, acquired digital fibrokeratoma, superficial angiomyxoma, myxoid neurofibroma, dermal mucinosis, sclerosing perineuroma, low grade fibromyxoid sarcoma, myxoid dermatofibrosarcoma protuberans, fibroma of tendon sheath, giant cell tumour, glomus tumour, fibrous histiocytoma, cutaneous myxoma and inflammatory myxohyaline tumour of distal extremities.[7]

Treatment

Complete excision, which typically prevents recurrence, and regular follow-up are recommended surgical therapy techniques.[7]

Outlook

Superficial acral fibromyxoma has a benign course.[3] Though it is possible for the tumor to convert into a low-grade malignant tumor, no malignant transition has been documented till 2001.[10] [11] There have been reports of 22–24% local recurrence rates.[4] [12]

Epidemiology

The majority of affected individuals are young adults (mean age: 46 years), with a 2:1 male to female ratio.[6]

See also

Further reading

External links

Notes and References

  1. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 978-1-4160-2999-1 .
  2. Park . Se-Won . Kim . Jun-Hwan . Shin . Hyun-Tae . Park . Ji Ho . Lee . Jong-Hee . Lee . Dong-Youn . Lee . Joo-Heung . Yang . Jun-Mo . Superficial Acral Fibromyxoma on the Palm . Annals of Dermatology . Korean Dermatological Association and The Korean Society for Investigative Dermatology . 26 . 1 . 2014 . 1013-9087 . 10.5021/ad.2014.26.1.123 . 123. 24648703 . 3956782 .
  3. Debordes . Pierre-Antoine . Hamoudi . Ceyran . Weingertner . Noelle . Di Marco . Antonio . Superficial acral fibromyxoma: a case of missed diagnosis . Journal of Surgical Case Reports . 2023 . 2 . 2023-02-01 . rjad027 . 2042-8812 . 36751671 . 9894613 . 10.1093/jscr/rjad027 .
  4. Fetsch . John F. . Laskin . William B. . Miettinen . Markku . Superficial acral fibromyxoma: A clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes . Human Pathology . Elsevier BV . 32 . 7 . 2001 . 0046-8177 . 10.1053/hupa.2001.25903 . 704–714. 11486169 .
  5. C . Ramya . Nayak . Chitra . Tambe . Swagata . Superficial acral fibromyxoma . Indian Journal of Dermatology . Medknow . 61 . 4 . 2016 . 457–459 . 0019-5154 . 10.4103/0019-5154.185734 . free . 27512201 . 4966414 .
  6. Goo . Jawoong . Jung . Ye-Jin . Kim . Jae-Hong . Lee . Sung-yul . Ahn . Sung Ku . A Case of Recurrent Superficial Acral Fibromyxoma . Annals of Dermatology . Korean Dermatological Association and The Korean Society for Investigative Dermatology . 22 . 1 . 2010 . 1013-9087 . 10.5021/ad.2010.22.1.110 . 110. 20548898 . 2883388 .
  7. Ashby-Richardson . Harty . Rogers . Gary S . Stadecker . Miguel J . Superficial Acral Fibromyxoma: An Overview . Archives of Pathology & Laboratory Medicine . 135 . 8 . 2011-08-01 . 0003-9985 . 10.5858/2009-0684-RSR1 . 1064–1066. 21810002 .
  8. Meyerle . CPT Jon H . Keller . COL Richard A . Krivda . LTC Stephen J . Superficial acral fibromyxoma of the index finger . Journal of the American Academy of Dermatology . Elsevier BV . 50 . 1 . 2004 . 0190-9622 . 10.1016/s0190-9622(03)00761-8 . 134–136. 14699384 .
  9. Kazakov . D.V. . Mentzel . T. . Burg . G. . Kempf . W. . Superficial Acral Fibromyxoma: Report of Two Cases . Dermatology . S. Karger AG . 205 . 3 . 2002 . 1018-8665 . 10.1159/000065853 . 285–288.
  10. Hollmann . Travis J. . Bovée . Judith V.M.G. . Fletcher . Christopher D.M. . Digital Fibromyxoma (Superficial Acral Fibromyxoma) . American Journal of Surgical Pathology . Ovid Technologies (Wolters Kluwer Health) . 36 . 6 . 2012 . 0147-5185 . 10.1097/pas.0b013e31824a0b83 . 789–798. 22367301 .
  11. Crepaldi . Bruno Eiras . Soares . Ruan Dalbem . Silveira . Fábio Duque . Taira . Raul Itocazo . Hirakawa . Celso Kiyoshi . Matsumoto . Marcelo Hide . Fibromixoma acral superficial: Revisão da Literatura . Revista Brasileira de Ortopedia . Georg Thieme Verlag KG . 54 . 5 . 2019 . 0102-3616 . 10.1016/j.rbo.2017.10.011 . 491–496 . pt. 6856000 .
  12. Al-Daraji . Wael I . Miettinen . Markku . Superficial acral fibromyxoma: a clinicopathological analysis of 32 tumors including 4 in the heel . Journal of Cutaneous Pathology . Wiley . 35 . 11 . 2008-10-10 . 0303-6987 . 10.1111/j.1600-0560.2007.00954.x . 1020–1026. 18537858 .

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