Aconitic acid explained
Aconitic acid is an organic acid. The two isomers are cis-aconitic acid and trans-aconitic acid. The conjugate base of cis-aconitic acid, cis-aconitate is an intermediate in the isomerization of citrate to isocitrate in the citric acid cycle. It is acted upon by the enzyme aconitase.
Aconitic acid can be synthesized by dehydration of citric acid using sulfuric acid:[1]
(HO2CCH2)2C(OH)CO2H → HO2CCH=C(CO2H)CH2CO2H + H2OA mixture of isomers are generated in this way.
Aconitic acid was originally isolated from Aconitum napellus by Swiss chemist and apothecary Jacques Peschier in 1820.[2] [3] It was first prepared by thermal dehydration.[4]
Like the conjugate bases of other polycarboxylic acid, acotinic acid forms a variety of coordination complexes. One example is the coordination polymer [Zn<sub>3</sub>(C<sub>6</sub>H<sub>3</sub>O<sub>6</sub>)<sub>2</sub>(H<sub>2</sub>O)<sub>6</sub>]n.[5]
Notes and References
- Bruce, W. F. . Aconitic Acid . Organic Syntheses . 1937 . 17 . 1. 10.15227/orgsyn.017.0001 .
- Book: Brande . William Thomas . A Manual of Chemistry, Vol II. . 1848 . John W. Parker. . London . 1344 . 6 . 8 November 2023.
- Book: Reichenbach . Karl-Rudolf . Jacques Peschier (1769-1832): Ein Genfer Apotheker und Chemiker . 2001 . Wissenschaftliche Verlagsgesellschaft mbH Stuttgart . Zürich . 3804719090 . 8 November 2023.
- Pawolleck, B. . Substitutionsproducte der Citronensäure und ein Versuch zur Synthese der letzteren . Substitution products of citric acid and an attempt at the synthesis of the latter . Justus Liebig's Annalen der Chemie . 1875 . 178 . 2–3 . 150–170 . 10.1002/jlac.18751780203 .
- 10.1016/j.ica.2008.10.008 . Synthesis and characterization of a novel photoluminescent three-dimensional metal–organic framework . 2009 . Zhang . Kou-Lin . Zhou . Fang . Yuan . Li-Min . Diao . Guo-Wang . Ng . Seik Weng . Inorganica Chimica Acta . 362 . 7 . 2510–2514 .
