Acetylspermidine deacetylase explained

acetylspermidine deacetylase
Ec Number:	3.5.1.48
Cas Number:	67339-07-5
Go Code:	0047611

In enzymology, an acetylspermidine deacetylase is an enzyme that catalyzes the chemical reaction

N₈-acetylspermidine + H₂O

\rightleftharpoons acetate + spermidine

Thus, the two substrates of this enzyme are N8-acetylspermidine and H₂O, whereas its two products are acetate and spermidine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N8-acetylspermidine amidohydrolase. Other names in common use include N8-monoacetylspermidine deacetylase, N8-acetylspermidine deacetylase, N-acetylspermidine deacetylase, N1-acetylspermidine amidohydrolase (incorrect), and 8-N-acetylspermidine amidohydrolase.

References

• Libby PR . 1978 . Properties of an acetylspermidine deacetylase from rat liver . Arch. Biochem. Biophys. . 188 . 360 - 3 . 28089 . 10.1016/S0003-9861(78)80020-4 . 2 .
• Blankenship J . 1978 . Deacetylation of N8-acetylspermidine by subcellular fractions of rat tissue . Arch. Biochem. Biophys. . 189 . 20 - 7 . 708044 . 10.1016/0003-9861(78)90109-1 . 1 .
• Marchant P, Manneh VA, Blankenship J . 1986 . N1-acetylspermidine is not a substrate for N-acetylspermidine deacetylase . Biochim. Biophys. Acta . 881 . 297 - 9 . 3955076 . 2 . 10.1016/0304-4165(86)90017-6.