| acetylornithine transaminase | |
| Ec Number: | 2.6.1.11 |
| Cas Number: | 9030-40-4 |
| Go Code: | 0003992 |
In enzymology, an acetylornithine transaminase is an enzyme that catalyzes the chemical reaction
N2-acetyl-L-ornithine + 2-oxoglutarate
\rightleftharpoons
Thus, the two substrates of this enzyme are N2-acetyl-L-ornithine and 2-oxoglutarate, whereas its two products are N-acetyl-L-glutamate 5-semialdehyde and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase. Other names in common use include acetylornithine delta-transaminase, ACOAT, acetylornithine 5-aminotransferase, acetylornithine aminotransferase, N-acetylornithine aminotransferase, N-acetylornithine-delta-transaminase, N2-acetylornithine 5-transaminase, N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase, succinylornithine aminotransferase, and 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase. This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, pyridoxal phosphate.
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes,,,,, and .