Acetylglutamate kinase explained

acetylglutamate kinase
Ec Number:	2.7.2.8
Cas Number:	9027-58-1
Go Code:	0003991

In enzymology, an acetylglutamate kinase is an enzyme that catalyzes the chemical reaction:

ATP + N-acetyl-L-glutamate

\rightleftharpoons ADP + N-acetyl-L-glutamyl 5-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-L-glutamate, whereas its two products are ADP and N-acetyl-L-glutamyl 5-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. This enzyme participates in urea cycle and metabolism of amino groups.

Nomenclature

The systematic name of this enzyme class is ATP:N-acetyl-L-glutamate 5-phosphotransferase. Other names in common use include:

• N-acetylglutamate 5-phosphotransferase,
• acetylglutamate phosphokinase,
• N-acetylglutamate phosphokinase,
• N-acetylglutamate kinase, and
• N-acetylglutamic 5-phosphotransferase.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,, and .

References

• Baich A, Vogel HJ . 1962 . N-Acetyl-gamma-Ilutamokinase and N-acetylglutamic gamma-semialdehyde dehydrogenase: repressible enzymes of arginine synthesis in Escherichia coli . Biochem. Biophys. Res. Commun. . 7 . 6 . 491 - 6 . 13863980 . 10.1016/0006-291X(62)90342-X .
• Farago A, Denes G . 1967 . Mechanism of arginine biosynthesis in Chlamydomonas reinhardti. II Purification and properties of N-acetylglutamate 5-phosphotransferase, the allosteric enzyme of the pathway . Biochim. Biophys. Acta . 136 . 6 - 18 . 6040410 . 1 . 10.1016/0304-4165(67)90315-7 .
• Book: Vogel HJ, McLellan WL. 1970 . N-Acetyl-gamma-glutamokinase (Escherichia coli) . [24b] N-acetyl-γ-glutamokinase (Escherichia coli) . Methods Enzymol. . 17A . 251 - 255 . 10.1016/0076-6879(71)17190-x. 978-0-12-181874-6 .