Acetophenone carboxylase explained

Acetophenone carboxylase
Ec Number:	6.4.1.8

Acetophenone carboxylase is an enzyme with systematic name acetophenone:carbon-dioxide ligase (ADP-forming).^[1] This enzyme catalyses the following chemical reaction

2 ATP + acetophenone + HCO₃⁻ + H₂O + H⁺

\rightleftharpoons 2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate

The enzyme is involved in anaerobic degradation of ethylbenzene.

Notes and References

1. Jobst B, Schühle K, Linne U, Heider J . ATP-dependent carboxylation of acetophenone by a novel type of carboxylase . Journal of Bacteriology . 192 . 5 . 1387–94 . March 2010 . 20047908 . 2820866 . 10.1128/jb.01423-09 .