Acetone carboxylase explained

Acetone carboxylase
Ec Number:	6.4.1.6
Go Code:	0018710

In enzymology, an acetone carboxylase is an enzyme that catalyzes the chemical reaction

acetone + CO₂ + ATP + 2 H₂O

\rightleftharpoons acetoacetate + AMP + 2 phosphate

The 4 substrates of this enzyme are acetone, CO₂, ATP, and H₂O, whereas its 3 products are acetoacetate, AMP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is acetone:carbon-dioxide ligase (AMP-forming).

References

• Sluis MK, Ensign SA . 1997 . Purification and characterization of acetone carboxylase from Xanthobacter strain Py2 . Proc. Natl. Acad. Sci. U.S.A. . 94 . 8456 - 61 . 9237998 . 10.1073/pnas.94.16.8456 . 16 . 22955 . free .