Acetoacetyl-CoA hydrolase explained

acetoacetyl-CoA hydrolase
Ec Number:	3.1.2.11
Cas Number:	37288-10-1
Go Code:	0047603

The enzyme acetoacetyl-CoA hydrolase (EC 3.1.2.11) catalyzes the reaction

acetoacetyl-CoA + H₂O

\rightleftharpoons CoA + acetoacetate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is acetoacetyl-CoA hydrolase. Other names in common use include acetoacetyl coenzyme A hydrolase, acetoacetyl CoA deacylase, and acetoacetyl coenzyme A deacylase. This enzyme participates in butanoate metabolism.

References

• Aragon JJ, Lowenstein JM . 1983 . A survey of enzymes which generate or use acetoacetyl thioesters in rat liver . J. Biol. Chem. . 258 . 4725 - 33 . 6131897 . 8 .
• Drummond GI, Stern JR . 1960 . Enzymes of ketone body metabolism. II. Properties of an acetoacetate-synthesizing enzyme prepared from ox liver . J. Biol. Chem. . 235 . 318 - 25 . 13818236 .