| Acetoacetate—CoA ligase | |
| Ec Number: | 6.2.1.16 |
| Cas Number: | 39394-62-2 |
| Go Code: | 0030729 |
In enzymology, an acetoacetate—CoA ligase is an enzyme that catalyzes the chemical reaction
ATP + acetoacetate + CoA
\rightleftharpoons
The 3 substrates of this enzyme are ATP, acetoacetate, and CoA, whereas its 3 products are AMP, diphosphate, and acetoacetyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetoacetate:CoA ligase (AMP-forming). This enzyme is also called acetoacetyl-CoA synthetase. This enzyme participates in butanoate metabolism.