A-1,3-mannosyl-glycoprotein 4-b-N-acetylglucosaminyltransferase explained

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Ec Number:2.4.1.145
Cas Number:86498-16-0

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase IV, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV, beta-acetylglucosaminyltransferase IV, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV, alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase, GnTIV) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase.[1] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

\rightleftharpoons

UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.

Notes and References

  1. Gleeson PA, Schachter H . Control of glycoprotein synthesis . The Journal of Biological Chemistry . 258 . 10 . 6162–73 . May 1983 . 6222042 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "A-1,3-mannosyl-glycoprotein 4-b-N-acetylglucosaminyltransferase".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.