| Honorific-Prefix: | Senator |
| Zulfiqar Ali Khosa | |
| President: | Muhammad Rafiq Tarar |
| Primeminister: | Nawaz Sharif |
| Nationality: | Pakistani |
| Spouse: | Nadra Begum [1] |
| Office: | Governor of Punjab |
| Termstart: | August 12, 1999 |
| Termend: | October 12, 1999 |
| Office1: | Member of the Senate of Pakistan |
| Termstart1: | 12 March 2012 |
| Termend1: | 12 March 2018 |
| Birth Date: | 1935 10, df=yes |
| Primeminister1: | Shahid Khaqan Abbasi |
| Children: | Dost Muhammad Khosa (son) Muhammad Saif-ud-Din Khosa (son) |
| Relations: | Sardar Muhammad Mohiuddin Khosa (grandson) Latif Khosa (cousin) Amjad Farooq Khan (cousin) |
| Otherparty: | PTI (2018-2023) PMLN (1993-2018) Islami Jamhoori Ittehad (1988-1993) Independent (1985-1988) |
| Constituency1: | General seat from Punjab |
| Office2: | Member of the Provincial Assembly of the Punjab |
| Term Start2: | 3 July 2008 |
| Term End2: | 12 March 2012 |
| Constituency2: | PP-243 Dera Ghazi Khan-IV |
| Term Start3: | 18 February 1997 |
| Term End3: | 12 October 1999 |
| Constituency3: | PP-201 Dera Ghazi Khan-III |
| Term Start4: | 18 October 1993 |
| Term End4: | 17 November 1996 |
| Constituency4: | PP-201 Dera Ghazi Khan-III |
| Term Start5: | 5 November 1990 |
| Term End5: | 28 June 1993 |
| Constituency5: | PP-201 Dera Ghazi Khan-III |
| Term Start6: | 30 November 1988 |
| Term End6: | 6 August 1990 |
| Constituency6: | PP-201 Dera Ghazi Khan-III |
| Term Start7: | 12 March 1985 |
| Term End7: | 30 May 1988 |
| Constituency7: | PP-184 Dera Ghazi Khan-I |
| Term Start8: | 9 April 1977 |
| Term End8: | 5 July 1977 |
| Constituency8: | PP-192 Dera Ghazi Khan-VII |
| Term Start9: | 9 June 1962 |
| Term End9: | 8 June 1965 |
| Constituency9: | Dera Ghazi Khan-II |
| Office9: | Member of the West Pakistan Assembly |
Sardar Zulfiqar Ali Khosa (Urdu: {{Nastaliq|ذوالفقار علی کھوسہ; born 20 October 1935) is a Pakistani political leader, former senator and former Governor of Punjab. He represented Punjab, Pakistan in the Senate of Pakistan. Sardar Zulfiqar Ali Khan has been elected to the Provincial Assembly of Punjab for eight tenures in 1970, 1977, 1985, 1988, 1990, 1993, 1997 and 2008. He was also elected to the West Pakistan Assembly in 1962. Khosa also contested for a National Assembly of Pakistan in general election 2018 but lost to Amjad Farooq Khan.
Khosa is one of the most seniors politicians of Pakistan and is famous for his consistent control in the Politics of Punjab from 1986 to 2018.He comes from a Baloch Khosa tribe. He was born in Bahadurgarh, Dera Ghazi Khan District, Punjab, British India .
He became the Tumandar of the Khosa in 1935 after the death of his father, Dost Muhammad Khan Khosa.[2]
He was the Governor of the Punjab from 17 August 1999 to 12 October 1999. He was a senator from Punjab, Pakistan, from 2012 to 2018.
He has three sons: Hissam Uddin Khan Khosa, Saif Uddin Khan Khosa, and Dost Muhammad Khosa.