Zuclomifene Explained

Zuclomifene (INN; or zuclomiphene (USAN)) is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that was never marketed.^{[1] [2] [3] [4]} It is one of the two stereoisomers of clomifene, which itself is a mixture of 38% zuclomifene and 62% enclomifene. Zuclomifene is the (Z)-stereoisomer of clomifene, while enclomifene is the (E)-stereoisomer. Whereas zuclomifene is described as mildly estrogenic, enclomifene is described as antiestrogenic.^[5] In accordance, unlike enclomifene, zuclomifene is antigonadotropic due to activation of the estrogen receptor and reduces testosterone levels in men. It is also about five times more potent than enclomifene in inducing ovulation.

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 298–.
2. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 31 October 1999. Springer Science & Business Media. 978-0-7514-0499-9. 79–.
3. Web site: Enclomifene - Repros Therapeutics . AdisInsight . Springer Nature Switzerland AG .
4. Hill S, Arutchelvam V, Quinton R . Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men . IDrugs . 12 . 2 . 109–119 . February 2009 . 19204885 .
5. Book: Luniwal A, Jetson R, Erhardt P . Selective Estrogen Receptors Modulators . Fischer J, Ganellin CR, Rotella DP . Analogue-based Drug Discovery III. https://books.google.com/books?id=BP2Bo11gTOMC&pg=SA5-PA58. 15 October 2012. John Wiley & Sons. 978-3-527-65110-8. 5–.