Zolazepam Explained

Zolazepam[1] (Flupyrazapon) is a pyrazolodiazepinone derivative structurally related to the benzodiazepine drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine or the α2 adrenergic receptor agonist xylazine, depending on what purpose it is being used for. It is 5-10 times the potency of diazepam.[2]

Zolazepam was developed by Horace A. de Wald and Donald E. Butler for Parke-Davis[3] and was the result of a very detailed analysis of the benzodiazepine structure (filed in 1969).

Zolazepam, in combination with tiletamine, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be superior to ketamine because of reduced side-effects.[4] [5] A 1:1 mixture of zolazepam and tiletamine is sold under the names Telazol and Zoletil.

See also

Notes and References

  1. US. 3879535. Anesthetic compositions and methods of use. 1975-04-22. Parke, Davis & Co.. Stoliker. Harry E..
  2. DeWald HA, Lobbestael S, Butler DE . Pyrazolodiazepines. 2. 4-Aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e] [1,4]diazepin-7(1H)-ones as antianxiety and anticonvulsant agents . Journal of Medicinal Chemistry . 20 . 12 . 1562–9 . December 1977 . 22748 . 10.1021/jm00222a005 .
  3. DE. 2023453. 1970-11-19. Pyrazolo[3,4-e],[1,4]diazepin-7(1H)-on Verbindungen und ihre pharmazeutisch zulässigen Salze [Pyrazolo[3,4-e],[1.4]diazepin-7(lH)-one compounds and their pharmaceutically acceptable salts]. Parke, Davis & Co.. DeWald. Horace Albert. Butler. Donald Eugene.
  4. Sleeman JM, Cameron K, Mudakikwa AB, Nizeyi JB, Anderson S, Cooper JE, Richardson HM, Macfie EJ, Hastings B, Foster JW . 6 . Field anesthesia of free-living mountain gorillas (Gorilla gorilla beringei) from the Virunga Volcano region, Central Africa . Journal of Zoo and Wildlife Medicine . 31 . 1 . 9–14 . March 2000 . 10884117 . 10.1638/1042-7260(2000)031[0009:faoflm]2.0.co;2 . 20623485 .
  5. Cattet MR, Caulkett NA, Polischuk SC, Ramsay MA . Anesthesia of polar bears (Ursus maritimus) with zolazepam-tiletamine, medetomidine-ketamine, and medetomidine-zolazepam-tiletamine . Journal of Zoo and Wildlife Medicine . 30 . 3 . 354–60 . September 1999 . 10572857 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Zolazepam".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.