Ziyad Al-Aly Explained

Ziyad Al-Aly is an American physician and clinical epidemiologist who is currently Director of the Clinical Epidemiology Center and Chief of the Research and Development at the Veterans Affairs St. Louis Health Care System.[1] [2] [3] He is also a clinical epidemiologist at Washington University in St. Louis.[2] He has led multiple studies on long covid and its sequelae.[4]

Early life

Al-Aly was born in Tripoli, Lebanon to teachers.[5] He grew up during the Lebanese civil war which dominated Lebanon from 1975 to 1990, emigrating to the United States in 2000.

Education

Al-Aly holds a medical degree from the American University of Beirut.[6] He completed his post-graduate medical education at Saint Louis University and Washington University in St. Louis.

Career

Al-Aly's research work has been cited more than a 120,000 times and he has an h-index of more than 80 according to Google Scholar.[7]

Long COVID research

Al-Aly led work which provided the first systematic characterization of the post-acute sequelae of SARS-CoV-2 infection.[8] He subsequently led work which characterized the increased risks of cardiovascular disease,[9] neurologic disorders,[10] mental health disorders,[11] gastrointestinal disorders,[12] diabetes,[13] dyslipidemia,[14] and kidney disease[15] following SARS-CoV-2 infection. His lab also produced evidence characterizing the effects of COVID-19 vaccines on long COVID[16] and the health consequences of repeated infections with SARS-CoV-2.[17]

In 2024, Al-Aly testified before the U.S. Senate Health, Education, Labor and Pensions Committee as an expert witness on Long Covid. He called for the establishment of an NIH institute to address Long Covid and Infection-Associated Chronic Conditions (IACCs) — also called post-acute infection syndrome — with a funding of at least $1 billion per year.[18]

Pharmacoepidemiology

Including work characterizing the adverse health effect of proton pump inhibitors and comparative effectiveness of antihyperglycemic medications. His work also included examining the effectiveness of COVID-19 antivirals including paxlovid (nirmatrelvir/ritonavir) and molnupiravir on acute COVID-19 outcomes[19] [20] and long COVID.[21] [22]

Environmental epidemiology research

Including work which evaluated the effect of air pollution on kidney health,[23] diabetes,[24] and early mortality.[25]

Honors and awards

In 2023, Al-Aly was awarded the U.S. Department of Veterans Affairs Secretary's Award — the highest VA award — for outstanding contributions to research. He was named one of the 100 most influential people in health in 2024 by TIME100 Health.

External links

Notes and References

  1. News: Repeat coronavirus infections can still be dangerous, study suggests . . 11 November 2022.
  2. Web site: Ziyad Al-Aly, MD . . 11 November 2022.
  3. Web site: Outlook Magazine . Washington University in Saint Louis . 2023-06-21 . Real-world reflections . 2023-08-03 . Outlook Magazine . en-US.
  4. Web site: COVID-19 infections increase risk of long-term brain problems . . 22 September 2022 . 11 November 2022.
  5. Web site: Outlook Magazine . Washington University in Saint Louis . 2023-06-21 . Real-world reflections . 2023-08-05 . Outlook Magazine . en-US.
  6. Web site: Ziyad Al-Aly, MD, FASN . . 11 November 2022.
  7. Web site: Ziyad Al-Aly, MD . . 11 January 2024.
  8. Al-Aly . Ziyad . Xie . Yan . Bowe . Benjamin . June 2021 . High-dimensional characterization of post-acute sequelae of COVID-19 . Nature . en . 594 . 7862 . 259–264 . 10.1038/s41586-021-03553-9 . 33887749 . 2021Natur.594..259A . 233373053 . 1476-4687. free .
  9. Xie . Yan . Xu . Evan . Bowe . Benjamin . Al-Aly . Ziyad . March 2022 . Long-term cardiovascular outcomes of COVID-19 . Nature Medicine . en . 28 . 3 . 583–590 . 10.1038/s41591-022-01689-3 . 35132265 . 8938267 . 1546-170X.
  10. Xu . Evan . Xie . Yan . Al-Aly . Ziyad . November 2022 . Long-term neurologic outcomes of COVID-19 . Nature Medicine . en . 28 . 11 . 2406–2415 . 10.1038/s41591-022-02001-z . 36138154 . 9671811 . 1546-170X.
  11. Xie . Yan . Xu . Evan . Al-Aly . Ziyad . 2022-02-16 . Risks of mental health outcomes in people with covid-19: cohort study . BMJ . en . 376 . e068993 . 10.1136/bmj-2021-068993 . 1756-1833 . 35172971. 8847881 .
  12. Xu . Evan . Xie . Yan . Al-Aly . Ziyad . 2023-03-07 . Long-term gastrointestinal outcomes of COVID-19 . Nature Communications . en . 14 . 1 . 983 . 10.1038/s41467-023-36223-7 . 36882400 . 9992516 . 2023NatCo..14..983X . 2041-1723.
  13. Xie . Yan . Al-Aly . Ziyad . 2022-05-01 . Risks and burdens of incident diabetes in long COVID: a cohort study . The Lancet Diabetes & Endocrinology . English . 10 . 5 . 311–321 . 10.1016/S2213-8587(22)00044-4 . 2213-8587 . 35325624. 8937253 .
  14. Xu . Evan . Xie . Yan . Al-Aly . Ziyad . 2023-02-01 . Risks and burdens of incident dyslipidaemia in long COVID: a cohort study . The Lancet Diabetes & Endocrinology . English . 11 . 2 . 120–128 . 10.1016/S2213-8587(22)00355-2 . 2213-8587 . 36623520. 9873268 .
  15. Bowe . Benjamin . Xie . Yan . Xu . Evan . Al-Aly . Ziyad . November 2021 . Kidney Outcomes in Long COVID . Journal of the American Society of Nephrology . en-US . 32 . 11 . 2851–2862 . 10.1681/ASN.2021060734 . 34470828 . 8806085 . 237389462 . 1046-6673.
  16. Al-Aly . Ziyad . Bowe . Benjamin . Xie . Yan . July 2022 . Long COVID after breakthrough SARS-CoV-2 infection . Nature Medicine . en . 28 . 7 . 1461–1467 . 10.1038/s41591-022-01840-0 . 35614233 . 9307472 . 1546-170X.
  17. Bowe . Benjamin . Xie . Yan . Al-Aly . Ziyad . November 2022 . Acute and postacute sequelae associated with SARS-CoV-2 reinfection . Nature Medicine . en . 28 . 11 . 2398–2405 . 10.1038/s41591-022-02051-3 . 36357676 . 9671810 . 1546-170X.
  18. Web site: Testimony of Ziyad Al-Aly, M.D., Clinical Epidemiologist, Washington University in Saint Louis, Saint Louis, MO Before United States Senate Committee on Health, Education, Labor and Pensions . January 18, 2024 . https://web.archive.org/web/20240118191245/https://www.help.senate.gov/imo/media/doc/baf4e4e7-b423-6bef-7cb4-1b272df66eb8/Al-Aly%20Testimony.pdf . 2024-01-18 . U.S. Senate Committee on Health, Education, Labor and Pensions.
  19. Xie . Yan . Bowe . Benjamin . Al-Aly . Ziyad . 2023-04-11 . Nirmatrelvir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records . BMJ . 381 . en . e073312 . 10.1136/bmj-2022-073312 . 1756-1833 . 10086514 . 37041016.
  20. Xie . Yan . Bowe . Benjamin . Al-Aly . Ziyad . 2023-03-07 . Molnupiravir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records . BMJ . 380 . en . e072705 . 10.1136/bmj-2022-072705 . 1756-1833 . 9989554 . 36882199.
  21. Xie . Yan . Choi . Taeyoung . Al-Aly . Ziyad . 2023-06-01 . Association of Treatment With Nirmatrelvir and the Risk of Post–COVID-19 Condition . JAMA Internal Medicine . en . 183 . 6 . 554–564 . 10.1001/jamainternmed.2023.0743 . 2168-6106 . 10037200 . 36951829.
  22. Xie . Yan . Choi . Taeyoung . Al-Aly . Ziyad . 2023-04-25 . Molnupiravir and risk of post-acute sequelae of covid-19: cohort study . BMJ . 381 . en . e074572 . 10.1136/bmj-2022-074572 . 1756-1833 . 10126525 . 37161995.
  23. Bowe . Benjamin . Xie . Yan . Li . Tingting . Yan . Yan . Xian . Hong . Al-Aly . Ziyad . January 2018 . Particulate Matter Air Pollution and the Risk of Incident CKD and Progression to ESRD . Journal of the American Society of Nephrology . en-US . 29 . 1 . 218–230 . 10.1681/ASN.2017030253 . 28935655 . 1046-6673. 5748906 .
  24. Bowe . Benjamin . Xie . Yan . Li . Tingting . Yan . Yan . Xian . Hong . Al-Aly . Ziyad . July 2018 . The 2016 global and national burden of diabetes mellitus attributable to PM 2·5 air pollution . The Lancet Planetary Health . 2 . 7 . e301–e312 . 10.1016/s2542-5196(18)30140-2 . 30074893 . 2542-5196. free .
  25. Bowe . Benjamin . Xie . Yan . Yan . Yan . Al-Aly . Ziyad . 2019-11-20 . Burden of Cause-Specific Mortality Associated With PM 2.5 Air Pollution in the United States . JAMA Network Open . en . 2 . 11 . e1915834 . 10.1001/jamanetworkopen.2019.15834 . 2574-3805 . 6902821 . 31747037.

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