Zinc finger protein basonuclin-2 explained

Zinc finger protein basonuclin-2 is a protein that in humans is encoded by the BNC2 gene.^{[1] [2]} BNC2 has recently been shown to influence skin pigmentation levels in Europeans.^[3] Genomic region spanning the BNC2 gene has 60% Neanderthal DNA sequence.^[4]

See also

• Chromosome 9 (human)
• Zinc finger protein

Further reading

• Vanhoutteghem A, Djian P . The human basonuclin 2 gene has the potential to generate nearly 90,000 mRNA isoforms encoding over 2000 different proteins . Genomics . 89 . 1 . 44–58 . Jan 2007 . 16942855 . 10.1016/j.ygeno.2006.07.006 .
• Vanhoutteghem A, Djian P . Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions . Proceedings of the National Academy of Sciences of the United States of America . 103 . 33 . 12423–8 . Aug 2006 . 16891417 . 1567895 . 10.1073/pnas.0605086103 . 2006PNAS..10312423V . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Benevolenskaya EV, Murray HL, Branton P, Young RA, Kaelin WG . Binding of pRB to the PHD protein RBP2 promotes cellular differentiation . Molecular Cell . 18 . 6 . 623–35 . Jun 2005 . 15949438 . 10.1016/j.molcel.2005.05.012 . free .
• Romano RA, Li H, Tummala R, Maul R, Sinha S . Identification of Basonuclin2, a DNA-binding zinc-finger protein expressed in germ tissues and skin keratinocytes . Genomics . 83 . 5 . 821–33 . May 2004 . 15081112 . 10.1016/j.ygeno.2003.11.009 .
• Vanhoutteghem A, Djian P . Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin . Proceedings of the National Academy of Sciences of the United States of America . 101 . 10 . 3468–73 . Mar 2004 . 14988505 . 373485 . 10.1073/pnas.0400268101 . 2004PNAS..101.3468V . free .

Notes and References

1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S . 6 . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nature Genetics . 36 . 1 . 40–5 . Jan 2004 . 14702039 . 10.1038/ng1285 . free .
2. Web site: Entrez Gene: BNC2 basonuclin 2.
3. Jacobs LC, Wollstein A, Lao O, Hofman A, Klaver CC, Uitterlinden AG, Nijsten T, Kayser M, Liu F . Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans . Human Genetics . 132 . 2 . 147–58 . Feb 2013 . 23052946 . 10.1007/s00439-012-1232-9 . 6057298 .
4. Vattathil S, Akey JM . Small Amounts of Archaic Admixture Provide Big Insights into Human History . Cell . 163 . 2 . 281–4 . Oct 2015 . 26451479 . 10.1016/j.cell.2015.09.042 . free .