Zinc finger protein ZFPM1 explained

Zinc finger protein ZFPM1 also known as friend of GATA protein 1 (FOG-1) is a protein that in humans is encoded by the ZFPM1 gene.^[1] It is a cofactor of the GATA1 transcription factor.

Further reading

• Tsang AP, Visvader JE, Turner CA, etal . FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. . Cell . 90 . 1 . 109–19 . 1997 . 9230307 . 10.1016/S0092-8674(00)80318-9 . 2085524 . free .
• Turner J, Crossley M . Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. . EMBO J. . 17 . 17 . 5129–40 . 1998 . 9724649 . 10.1093/emboj/17.17.5129 . 1170841 .
• Mehaffey MG, Newton AL, Gandhi MJ, etal . X-linked thrombocytopenia caused by a novel mutation of GATA-1. . Blood . 98 . 9 . 2681–8 . 2001 . 11675338 . 10.1182/blood.V98.9.2681 . free .
• Yu C, Niakan KK, Matsushita M, etal . X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. . Blood . 100 . 6 . 2040–5 . 2002 . 12200364 . 10.1182/blood-2002-02-0387 . 2808424 .
• Freson K, Thys C, Wittewrongel C, etal . Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions. . Hum. Genet. . 112 . 1 . 42–9 . 2003 . 12483298 . 10.1007/s00439-002-0832-1 . 7394526 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation. . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Liew CK, Simpson RJ, Kwan AH, etal . Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction. . Proc. Natl. Acad. Sci. U.S.A. . 102 . 3 . 583–8 . 2005 . 15644435 . 10.1073/pnas.0407511102 . 545545 . 2005PNAS..102..583L . free .
• Vannucchi AM, Pancrazzi A, Guglielmelli P, etal . Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis. . Am. J. Pathol. . 167 . 3 . 849–58 . 2005 . 16127162 . 10.1016/S0002-9440(10)62056-1. 1698737 .
• Yang HY, Kim SH, Kim SH, etal . The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells . Biochem. Biophys. Res. Commun. . 353 . 4 . 978–84 . 2007 . 17207461 . 10.1016/j.bbrc.2006.12.155 .

Notes and References

1. Web site: Entrez Gene: ZFPM1 zinc finger protein, multitype 1.