Zinc finger protein 266 explained
Zinc finger protein 266 is a protein that in humans is encoded by the ZNF266 gene.[1]
Function
This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene.
Further reading
- Liu X, Jin EZ, Zhi JX, Li XQ . Identification of HZF1 as a novel target gene of the MEF2 transcription factor . Molecular Medicine Reports . 4 . 3 . 465–9 . 2011 . 21468593 . 10.3892/mmr.2011.465 . free .
- Abrink M, Aveskogh M, Hellman L . Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937 . DNA and Cell Biology . 14 . 2 . 125–36 . Feb 1995 . 7865130 . 10.1089/dna.1995.14.125.
- Peng H, Du ZW, Zhang JW . Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells . Leukemia . 20 . 6 . 1109–16 . Jun 2006 . 16628192 . 10.1038/sj.leu.2404212 .
- Li XB, Chen J, Deng MJ, Wang F, Du ZW, Zhang JW . Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1 . Molecular Medicine Reports . 4 . 6 . 1131–7 . 2011 . 21874239 . 10.3892/mmr.2011.564 . free .
- Deng MJ, Li XB, Peng H, Zhang JW . Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16) . Molecular Biotechnology . 44 . 2 . 83–9 . Feb 2010 . 19763908 . 10.1007/s12033-009-9210-8 . 3470718 .
- Gamsjaeger R, Liew CK, Loughlin FE, Crossley M, Mackay JP . Sticky fingers: zinc-fingers as protein-recognition motifs . Trends in Biochemical Sciences . 32 . 2 . 63–70 . Feb 2007 . 17210253 . 10.1016/j.tibs.2006.12.007 .
- Fransen K, Visschedijk MC, van Sommeren S, Fu JY, Franke L, Festen EA, Stokkers PC, van Bodegraven AA, Crusius JB, Hommes DW, Zanen P, de Jong DJ, Wijmenga C, van Diemen CC, Weersma RK . Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease . Human Molecular Genetics . 19 . 17 . 3482–8 . Sep 2010 . 20601676 . 10.1093/hmg/ddq264 .
Notes and References
- Web site: Entrez Gene: Zinc finger protein 266. 2015-08-03 .
