Zinc D-Ala-D-Ala carboxypeptidase explained
| Zinc D-Ala-D-Ala carboxypeptidase |
| Ec Number: | 3.4.17.14 |
| Cas Number: | 213189-85-6 |
Zinc D-Ala-D-Ala carboxypeptidase (Zn2+ G peptidase, D-alanyl-D-alanine hydrolase, D-alanyl-D-alanine-cleaving carboxypeptidase, DD-carboxypeptidase, G enzyme, DD-carboxypeptidase-transpeptidase) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction
Cleavage of the bond: (Ac)2-L-lysyl-D-alanyl--D-alanine
This is a zinc enzyme. Catalyses carboxypeptidation but not transpeptidation reactions involved in bacterial cell wall metabolism.
Notes and References
- Dideberg O, Charlier P, Dive G, Joris B, Frère JM, Ghuysen JM . Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 A resolution . Nature . 299 . 5882 . 469–70 . September 1982 . 7121588 . 10.1038/299469a0 .
- Joris B, Van Beeumen J, Casagrande F, Gerday C, Frère JM, Ghuysen JM . The complete amino acid sequence of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of streptomyces albus G . European Journal of Biochemistry . 130 . 1 . 53–69 . January 1983 . 6825689 . 10.1111/j.1432-1033.1983.tb07116.x . free .
- Ghuysen JM, Frère JM, Leyh-Bouille M, Nguyen-Distèche M, Coyette J, Dusart J, Joris B, Duez C, Dideberg O, Charlier P . Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics . Scandinavian Journal of Infectious Diseases. Supplementum . 42 . 17–37 . 1984 . 6597561 .
