| Zezehommachi Station | |
| Native Name: | 膳所本町駅 |
| Native Name Lang: | ja |
| Address: | 2-8 Zeze, Ōtsu-shi, Shiga-ken 520-0815 |
| Country: | Japan |
| Coordinates: | 34.9951°N 135.8894°W |
| Operator: | 20px Keihan Electric Railway |
| Line: | Ishiyama Sakamoto Line |
| Distance: | 3.8 km from |
| Platforms: | 2 side platforms |
| Code: | OT07 |
| Opened: | March 1, 1913 |
| Former: | Zeze (to 1938) |
| Passengers: | 1989 daily (boarding) |
| Pass Year: | FY2018 |
| Map Type: | Japan Shiga Prefecture#Japan |
| Map Dot Label: | Zezehommachi Station |
is a passenger railway station located in the city of Ōtsu, Shiga Prefecture, Japan, operated by the private railway company Keihan Electric Railway.
Zezehommachi Station is a station of the Ishiyama Sakamoto Line, and is 3.8 kilometers from the terminus of the line at .
The station consists of two opposed unnumbered side platforms connected by a level crossing. The station is unattended.
Zezehommachi Station was opened on March 1, 1913 as . It was renamed on August 20, 1938.
In fiscal 2018, the station was used by an average of 1989 passengers daily (boarding passengers only).[1]