Zelandopam Explained

Routes Of Administration:Intravenous administration
Class:Dopamine D1-like receptor agonists
Cas Number:139233-53-7
Cas Supplemental:
138086-00-7 (hydrochloride)
Pubchem:3078105
Chemspiderid:2336394
Unii:IR6XYD8SAX
Chembl:2105532
Synonyms:Selandopam; (–)-(S)-7,8-Dihydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline; 7,8-DDPTI; YM-435; YM435; MYD-37; MYD37
Iupac Name:(4S)-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline-7,8-diol
C:15
H:15
N:1
O:4
Smiles:C1[C@H](C2=C(CN1)C(=C(C=C2)O)O)C3=CC(=C(C=C3)O)O
Stdinchi:1S/C15H15NO4/c17-12-3-1-8(5-14(12)19)10-6-16-7-11-9(10)2-4-13(18)15(11)20/h1-5,10,16-20H,6-7H2/t10-/m0/s1
Stdinchikey:FULLEMQICAKPOE-JTQLQIEISA-N

Zelandopam (; developmental code names YM-435, MYD-37) is a selective dopamine D1-like receptor agonist related to fenoldopam which was under development in Japan for the treatment of hypertension and heart failure but was never marketed.[1] [2] [3] The drug was being developed for use by intravenous administration. The development of zelandopam appears to have been discontinued by the early 2000s. It was first described in the scientific literature by 1991.[4]

Notes and References

  1. Web site: Zelandopam hydrochloride . AdisInsight . 22 May 2002 . 21 October 2024.
  2. Doggrell SA . The therapeutic potential of dopamine modulators on the cardiovascular and renal systems . Expert Opin Investig Drugs . 11 . 5 . 631–644 . May 2002 . 11996645 . 10.1517/13543784.11.5.631 .
  3. Vaz de Castro PA, Jose PA, Simões e Silva AC . Interactions between the intrarenal dopaminergic and the renin-angiotensin systems in the control of systemic arterial pressure . Clin Sci (Lond) . 136 . 16 . 1205–1227 . August 2022 . 35979889 . 10.1042/CS20220338 .
  4. Giammattei, C. E., Handa, R. K., & Strandhoy, J. W. (1991). The DA1 agonists, YM435 (YM) and fenoldopam (F), inhibit oxygen consumption (QO2) in rat renal proximal tubules. Pharmacologist, 33, 210p. https://scholar.google.com/scholar?cluster=13521937496129958590