| Zane Trace High School | |
| Address: | 946 State Route 180 |
| City: | Chillicothe |
| State: | Ohio |
| Zipcode: | 45601 |
| Country: | United States |
| Schooltype: | Public |
| Principal: | Ty Wertman |
| Teaching Staff: | 25 |
| Grades: | 9-12 |
| Enrollment: | 444 (2016–17)[1] |
| Team Name: | Pioneers |
Zane Trace High School is a public high school near Chillicothe, Ohio, seated along the shores of Kinnikinnick Creek. It is the only high school in the Zane Trace Local School District. Their nickname is the Pioneers, and their colors are red, blue, and white. Their sports programs include: football, boys and girls cross country, boys and girls soccer, boys and girls basketball, volleyball, cheerleading, boys and girls track, boys and girls bowling, swimming, softball, baseball, wrestling, and e-sports.
Zane Trace takes its name from a frontier road built before Ohio statehood by Ebenezer Zane. The road followed historical Native American trails and passed by nearby Kinnikinnick Creek. Zane Trace Local School District was created in 1967 when the school districts of Centralia, Kingston, and Adelphi consolidated.
Zane Trace competes in the Scioto Valley Conference.