Zandelisib Explained

Legal Status:Investigational
Cas Number:1401436-95-0
Pubchem:66571003
Drugbank:DB18245
Chemspiderid:57617733
Unii:8Z28M5SX0X
Kegg:D12009
Chembl:4650214
Iupac Name:4-[2-(difluoromethyl)benzimidazol-1-yl]-N-[2-methyl-1-[2-(1-methylpiperidin-4-yl)phenyl]propan-2-yl]-6-morpholin-4-yl-1,3,5-triazin-2-amine
C:31
H:38
F:2
N:8
O:1
Smiles:CC(C)(CC1=CC=CC=C1C2CCN(CC2)C)NC3=NC(=NC(=N3)N4CCOCC4)N5C6=CC=CC=C6N=C5C(F)F
Stdinchi:1S/C31H38F2N8O/c1-31(2,20-22-8-4-5-9-23(22)21-12-14-39(3)15-13-21)38-28-35-29(40-16-18-42-19-17-40)37-30(36-28)41-25-11-7-6-10-24(25)34-27(41)26(32)33/h4-11,21,26H,12-20H2,1-3H3,(H,35,36,37,38)
Stdinchikey:WPFUFWIHMYZXSF-UHFFFAOYSA-N

Zandelisib is an investigational new drug that is being evaluated to treat follicular lymphoma.[1] It is a phosphatidylinositol 3 kinase delta inhibitor.[2]

Notes and References

  1. Web site: Zandelisib - MEI Pharma/Kyowa Kirin . AdisInsight . Springer Nature Switzerland AG .
  2. Hus I, Puła B, Robak T . PI3K Inhibitors for the Treatment of Chronic Lymphocytic Leukemia: Current Status and Future Perspectives . Cancers . 14 . 6 . March 2022 . 1571 . 35326722 . 8945984 . 10.3390/cancers14061571 . free .