Zaltoprofen Explained

Iupac Name:	2-(6-Oxo-5H-benzo[''b''][1]benzothiepin-3-yl)propanoic acid
Tradename:	Soleton
Legal Us:	Not FDA approved
Legal Status:	Japan: Rx-only
Cas Number:	74711-43-6
Unii:	H8635NG3PY
Class:	NSAID
Pubchem:	5720
Drugbank:	DB06737
Synonyms:	Zaxoprofen
C:	17
H:	14
O:	3
S:	1
Smiles:	CC(C1=CC2=C(C=C1)SC3=CC=CC=C3C(=O)C2)C(=O)O

Zaltoprofen (JAN; trade name Soleton) is a nonsteroidal anti-inflammatory drug (NSAID) used as an analgesic, antipyretic, and anti-inflammatory agent.^[1] It is a selective COX-2 inhibitor and also inhibits bradykinin-induced pain responses without blocking bradykinin receptors.^[2]

It was approved for use in Japan in 1993.^[3]

Notes and References

1. Web site: Zaltoprofen . drugs.com.
2. Hirate K, Uchida A, Ogawa Y, Arai T, Yoda K . Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors . Neuroscience Research . 54 . 4 . 288–94 . April 2006 . 16473424 . 10.1016/j.neures.2005.12.016 . 27367042 .
3. News: Zaltoprofen Launched in Japan . thepharmaletter.com . September 20, 1993.