Zalospirone Explained

Zalospirone (WY-47,846) is a selective 5-HT1A partial agonist of the azapirone chemical class.[1] [2] It was found to be effective in the treatment of anxiety and depression in clinical trials, but a high proportion of subjects dropped out due to side effects and development was subsequently never completed.[3]

See also

Notes and References

  1. Gleeson S, Barrett JE . 5-HT1A agonist effects on punished responding of squirrel monkeys . Pharmacology, Biochemistry, and Behavior . 37 . 2 . 335–7 . October 1990 . 1981937 . 10.1016/0091-3057(90)90344-H . 23488390 .
  2. Singh A, Lucki I . Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors . Neuropharmacology . 32 . 4 . 331–40 . April 1993 . 8497336 . 10.1016/0028-3908(93)90153-T . 38611829 .
  3. Rickels K, Derivan A, Kunz N, Pallay A, Schweizer E . Zalospirone in major depression: a placebo-controlled multicenter study . Journal of Clinical Psychopharmacology . 16 . 3 . 212–7 . June 1996 . 8784652 . 10.1097/00004714-199606000-00004 .

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