| Zakhele Manyatsi | |
| Fullname: | Zakhele Manyatsi |
| Birth Date: | 7 September 1980[1] |
| Birth Place: | Swaziland |
| Position: | Defender |
| Years1: | 2003–2005 |
| Clubs1: | Hub Sundowns |
| Years2: | 2005– |
| Clubs2: | Royal Leopards |
| Nationalyears1: | 2006– |
| Nationalcaps1: | 12 |
| Nationalgoals1: | 0 |
Zakhele Manyatsi (born 7 September 1980) is a Swaziland international footballer who plays as a defender. As of January 2010, he plays for Royal Leopards in the Swazi Premier League and has won 12 caps for his country.